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The NDNS Biorepository
Repository and residual biological samples collected from the different surveys have been stored to be available for further research, providing the opportunity for data linkage at the individual level.
The collection contains samples of urine, plasma, serum and whole blood from the current NDNS RP, urinary sodium surveys 2011-15 in England, Scotland and Northern Ireland, the Diet and Nutrition Survey of Infants and Young Children (DNSIYC) and past NDNS.
The NDNS Biorepository forms a key part of the NDNS Bioresource along with access to NDNS RP/DNSIYC participants for follow-up research and NHS data linkage.
What’s in the NDNS Biorepository collection?
The Biorepository contains urine, plasma, serum and whole blood samples. The tables below provide a provisional indication of the different surveys, dates of sample collection, age groups and sample size and approximate numbers of urine and blood samples. Sample amounts and types vary between the different surveys and for some of the earlier surveys, records are not fully inventoried and catalogued. If you would like further information about a specific age group, survey year or sample type please email: email@example.com for more specific information. Charges may apply.
|Survey||Survey year||Dates of sample collection||Population age||Dietary and other core variables data (n)||Urine samples (approx. n)a||Blood samples (approx. n)b|
|NDNS RP||Y1c||2008/09||1.5y – 18y||845||390||200|
|NDNS RP||Y2d||2008/10||1.5y – 18y||857||410||230|
|NDNS RP||Y3d||2008/11||1.5y – 18y||783||370||210|
|NDNS RP||Y4d||2008/12||1.5y – 18y||893||420||250|
|NDNS RP||Y5e||2008/13||1.5y – 18y||572||270||160|
|NDNS RP||Y6f||2008/14||1.5y – 18y||686||460||190|
|NDNS RP||Y7f||2008/15||1.5y – 18y||650||390||150|
|NDNS RP||Y8f||2008/16||1.5y – 18y||656||400||170|
|NDNS RP||Y9f||2008/17||1.5y – 18y||In progress|
a Urine samples for Years 1-5 were 24-hour urine collections, whereas urine samples for Years 6-9 were a single spot sample.
b Due to sample volume collected and varying consents, the total number available in the repository will be lower than the number of subjects originally in the project.
c There were country boosts for Scotland and Northern Ireland for this survey year.
d There were country boosts for Scotland, Northern Ireland and Wales for this survey year.
e There was a country boost for Wales only for this survey year.
f There were country boosts for Wales and Northern Ireland for this survey year.
|Survey||Dates of sample collection||Population age||Dietary and other core variables data (n)||Urine samples (approx. n)||Blood samples (approx. n)a|
|DNSYIC||2011||4 – 18 months||2683||n/a||460|
|Urinary Sodium Surveys|
|England||2014||19y – 64y||n/a||680||n/a|
|Scotland||2014||19y – 64y||n/a||660||n/a|
|Northern Ireland||2014||19y – 64y||n/a||600||n/a|
|England||2011||19y – 64y||n/a||540||n/a|
|Adults||2000-2001||19y – 64y||1724||To be catalogued||1000|
|Young People||1997||4y – 18y||1701||To be catalogued||To be catalogued|
|Older Adults||1994/95||65y+||1687||To be catalogued||To be catalogued|
|Pre-school Children||1992/93||1.5y – 4.5y||1675||n/a||To be catalogued|
aDue to sample volume collected and varying consents, the total number available in the repository will be lower than the number of subjects originally in the project.
How are samples collected and stored?
NDNS RP samples include samples obtained specifically for deposit in the NDNS Biorepository, and also residual material remaining after primary sample analysis, where participant consent has been granted. For details of how the blood and urine samples are obtained and processed in the NDNS RP (2008 – ongoing) see Appendix O and Appendix T of the NDNS Results from Years 1 to 4. Biological samples from other surveys are made up from residual sample post primary analysis.
Blood samples from the surveys are stored in -80ºC in mechanical freezers at MRC Elsie Widdowson Laboratory (MRC EWL). Urine samples are stored at -20 ºC also at MRC EWL.
MRC EWL is currently the custodian for the NDNS biological sample collection. Long term storage of donated samples for the surveys is with written participant consent and NHS ethics approval.
MRC EWL holds a Human Tissue Licence from the Human Tissue Licence Authority.